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As can be observed in this larger cohort ( n = 45 group), long-term L2-Cmu treatment tended to reduce female body weight (Fig

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9 The original Diabetes Prevention Program (DPP) trial, published in 2002, showed that intensive lifestyle change (a 7% weight loss target plus 150 minutes of physical activity per week) reduced the incidence of type 2 diabetes by 58% over 3 years