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Activation of the Nrf2 pathway enhances the transcription of antioxidant response element (ARE)-dependent genes such as heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), and glutamatecysteine ligase (GCL), thereby promoting detoxification of ROS and maintenance of redox homeostasis in oocytes (37)
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Fourth, the duration of the trial, 32 weeks, was insufficiently long to demonstrate the durability of glycemic and weight effects of CagriSema [10]
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