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Clinical trials in humans have been small in number and limited in scope
While traditional GLP-1 agonists have long been the standard for studying weight-related signaling, the addition of GIP receptor activation appears to modulate the adipocyte environment differently
Most patients shift to monthly injections after initial weekly repletion
They can range from 5% bioavailability to 100% bioavailability, depending on the patients metabolism in question
They can sometimes cause B12 levels to be too high
The optimal frequency, duration, and total number of courses for humans is entirely unknown
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