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We now know that patients frequently discontinue GLP-1 therapy within months, negating long-term benefits, and also struggle to meet the requirements of lifestyle changes that are prescribed alongside the medication
Participants with baseline retinopathy who achieved substantial A1c reductions within the first 16 weeks of treatment faced the highest risk of progression
Although some pharmacies may have workarounds, they are currently facing legal challenges
Additionally, mitochondrial dysfunction in AT under obese conditions can significantly increase respiration and biogenesis, promote fatty acid oxidation and alter metabolism, all of which lead to the production of excess acetyl-CoA (77, 78)
GI side effects affect 10% to 40% of GLP-1 users, particularly during the first few weeks and during each dose escalation
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