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One specific consideration for TB-500 is that it contains a methionine residue in the LKKTETQ active fragment region

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Intramuscular (IM) injections bypass the gastrointestinal tract entirely, making them particularly effective when oral absorption is unreliable or when a confirmed deficiency requires prompt correction

Animal research has found that it may have unsafe effects in pregnancy, especially in the first trimester

The duration of results can vary, but many patients experience ongoing benefits with continued use under medical supervision

Loren Pickart, who found that it caused older human liver tissue to produce proteins more characteristic of younger tissue.2 3 This resulted in GHK being originally described, specifically, as a liver cell growth factor