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Clinicians should refer to the BNF and NICE CKS guidance on NSAIDs for full prescribing information

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54 Based on the above studies, NAC, at a dose of 1200 mg per day, appears to have benefits in patients with NASH, with treatment durations of 48 weeks or more and in combination with metformin

Retatrutide can generate as much as 28.7% average weight loss at 68 weeks, compared to semaglutides lower percentage over approximately the same time period

Metformin is thought to have an anorexic effect partly by promoting the secretion of GLP-1 and activating afferent inputs from the intestinal tract to the NTS [24], but there is currently no evidence that the degree of weight loss exceeds 5%, which is the standard for use as an anti-obesity drug