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Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by GLP3
C.ElosegiJ
Tirzepatide is a dual GLP-1/GIP (glucose-dependent insulinotropic polypeptide) receptor agonist originally approved by the FDA for type 2 diabetes under the brand name Mounjaro and subsequently approved for chronic weight management as Zepbound
No significant interaction between the reduction in HbA1c levels and baseline BMI was observed in the subgroup analysis of the PIONEER program [24]
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