Very rarely on their own
Common side effects include anorexia, vomiting, headaches, diarrhea and nausea
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Restoring vitamin B12 can aid in red blood cell formation
It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway
It also plays a role in metabolism, can combat fatigue and improve exercise performance by enhancing muscle function and reducing muscle damage during workouts