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Zhao et al., 2018)

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MOTS-c might enhance metabolic benefits of exercise or provide some metabolic support when exercise is limited, but it is not a replacement

Hot flashes are not listed as a recognized adverse effect in the FDA-approved prescribing information for tirzepatide, and there is no established pharmacological mechanism directly linking tirzepatide to vasomotor symptoms

20 21 Legitimate anti-obesity medications, including semaglutide, tirzepatide and liraglutide, are proven treatments for obesity, Christopher McGowan, M.D., explains