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To overcome this issue, different treatment options have been developed, such as surgery (if the seizure is focal, i.e., originated from a specific region of a brain such as in the case of temporal lobe epilepsy in which the seizure originated from the hippocampus), ketogenic diet, deep brain stimulation (DBS), vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCR) (Harris and Angus-Leppan, 2020
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Further, it has been reported that GBM demonstrates three unique functional and morphologic esoteric niche such as perivascular, hypoxic, and invasive [64]
Lyon: IARC Press
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