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Meanwhile, Sph_12-38 has no significant cytotoxicity to human keratinocytes (HKs) at its high concentration (33.5 M)

Before you draw from the vial, hold it up to a light source

As described above for PABA/NO, JS-K, and GSNO, the NHGs, in accordance with GT expression patterns, contribute to chemotherapy by producing locally high levels of NO which can rapidly react with O 2 - to generate the potent oxidant peroxynitrite that, in turn causes extensive cellular damage, including the nitration of protein tyrosine residues (Kirsch et al., 2001)

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