The impact of MTX exposure and administration of spirulina, TQ, or their combination on the levels of MDA, reduced glutathione, and antioxidant enzymes in the liver tissues
The odor comes from trimethylamine (TMA) excretion through sweat and urine
In the STEP 3 randomised trial, once weekly semaglutide 2.4 mg used in obese adults without diabetes was associated with 4.9% incidence of gallbladder related disorders (mainly cholelithiasis) compared with 1.5% in the placebo group (1)
In RCTs comparing GLP-1RA and placebo, insulin doses were reduced before GLP-1RA initiation to avoid hypoglycemia, and close monitoring and insulin adjustments were done periodically
Considerations and Usage: These medications are typically prescribed in conjunction with lifestyle modifications, including diet and exercise, for optimal results
however, the study was not powered to demonstrate differences between subgroups