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Anaphylaxis following a B12 injection has been documented in medical literature, particularly in patients with a sensitivity to cobalt or cobalamin compounds
And anyone with severe renal impairment should discuss both compounds with their physician before proceeding
inject slowly and steadily [12]
Backed by Science
22 May 2026 6 min Why do I feel worse after my B12 injection
This is the reason why the fundamental criteria for injectable B12the route of administration and the severity of the underlying conditionhave not changed
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