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Sirtuin Activation and Glutathione Gene Expression SIRT1 and SIRT3, the NAD+-dependent deacetylases activated by rising NAD+ concentrations, regulate the transcription factor Nrf2

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In case of treatment failure, either primary non-response or secondary failure to anti-TNFs, TDM may dictate the best therapeutic strategy, either by modifying the dosing scheme or switching out of anti-TNF- therapy [135, 137]