Its really important to understand that how you take B12 matters
But if people ask me, Would you take it? I would say no, citing worries about the long-term effects on things like tumor growth and whether it can enhance already proven levers like good nutrition, sleep, and rehab
Gastrointestinal effects: the main titration bottleneck Nausea, diarrhea, constipation, and vomiting run around 40 to 44% overall, dose-dependent in how many people report them but mild-dominant in severity: severe events stay at or below about 1.7% in any category even at the top dose. In the obesity program the by-dose rates run nausea 25/29/28%, diarrhea 19/21/23%, and vomiting 8/11/13% at 5/10/15 mg. They concentrate during escalation and ease with time on a held dose
And for more rapid improvement intramuscular therapy is used, and it must be considered in patients with severe deficiency or severe neurologic symptoms
Reconstitution & Handling Each 5 mg vial is typically reconstituted with 2 mL of bacteriostatic water, yielding a 2.5 mg/mL working stock, though investigators may adjust volumes based on study design and dosing precision needs
Understanding the consequences of NNMT inhibition has implications for research into metabolic regulation and potential therapeutic applications