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The results showed that HIF-1 significantly increased intracellular ROS levels, primarily that of hydrogen peroxide (H 2 O 2

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Abbreviations APAP: Acetaminophen AILI: APAP-induced liver injury DILI: Drug-induced liver injury HDS: Herbals and dietary supplements ALF: Acute liver failure NAPQI: N-acetyl-p-benzoquinone imine GSH: Glutathione DAMPs: Damage-associated molecular patterns NAC: n-acetylcysteine KCs: Kupffer cells MoMF: Monocyte-derived macrophages Mincle: Macrophage-inducible C-type lectin SAP130: Spliceosome-associated protein 130 WT: Wild-type HSCs: Hepatic stellate cells TNF: Tumor necrosis factor IL: Interleukin ROS: Reactive oxygen species RNS: Reactive nitrogen species C1q: Complement 1q LSECs: Liver sinusoidal endothelial cells Mrp4: Multidrug resistance-associated protein 4 HMGB1: High-mobility group box1 OPN: Osteopontin CXCL: CXC motif chemokine ligand NE: Neutrophil elastase miR-233: MicroRNA-223 TLR9: Toll-like receptor 9 CLEC-2: C-type lectin-like receptor-2 NK: Natural killer NKT: Natural killer T IFN: Interferon SJL: Swiss Jim lambert DMSO: Dimethyl sulfoxide DCs: Dendritic cells mDCs: Myeloid dendritic cells pDCs: Plasmacytoid dendritic cells MHC: Major histocompatibility complex CCl 4 : Carbon tetrachloride CCL: CC motif chemokine ligand TGF: Transforming growth factor ILCs: Innate lymphoid cells PRRs: Pattern recognition receptors ICAM-1: Intercellular adhesion molecule-1 VCAM-1: Vascular cell adhesion molecule-1 MIP: Macrophage inflammatory protein HSPs: Heat shock proteins NF: Nuclear factor iNOS: Inducible nitric oxide synthesis SOCS: Suppressor of cytokine signaling NLRP3: NOD-like receptor thermal protein domain associated protein 3 IL-22BP: IL-22 binding protein LC3-II: PE-conjugated form of light chain 3 p-AMPK: Phosphorylation of AMP-activated kinase CSF: Colony stimulating factor M-CSF: Macrophage-CSF G-CSF: Granulocyte-CSF GM-CSF: Granulocytemacrophage-CSF IL-1RA: IL-1 receptor antagonist ERK: Extracellular regulated protein kinases STAT3: Signal transducer and activator of transcription 3 PRHs: Primary rat hepatocytes rhIL-11: Recombinant human IL-11 TNFsR: Tumor necrosis factor receptor sDR5-Fc: Soluble death receptor 5-Fc fusion protein TRAIL: TNF-related apoptosis-inducing ligand PDGF: Platelet-derived growth factor IRF-1: Interferon regulatory factor-1 HSC-CM: HSCs-derived paracrine factor cGAS: Cyclic GMP-AMP synthase EGF: Endothelial growth factor VEGF: Vascular endothelial growth factor SERPINB: Serine protease inhibitor family B HGF: Hepatocyte growth factor CCR: CC motif chemokine receptor CXCR: CXC chemokine receptor GRPR: Gastrin-releasing peptide receptor NRF2: Nuclear factor erythroid2-related factor 2 References Practice Parameters Committee of the American College of Gastroenterology, Chalasani NP, Maddur H, Russo MW, Wong RJ, Reddy KR

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