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GPx1 (/) mouse fibroblasts showed a decrease in protein kinase B (Akt) phosphorylation at Ser-473 during stimulation with hydrogen peroxide, while GPx1-under-expressed MCF-7 cells did not affect the expression and phosphorylation of p38 MAPK [52]
It should be the minimum effective dose
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Patients should not assume safety simply because no interaction is listed in standard references
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