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NICE guidelines (NG28) recommend GLP-1 receptor agonists for type 2 diabetes in specific circumstances, typically in combination with other treatments when certain criteria are met, including BMI thresholds
What does the clinical evidence say about GLP-1 and muscle or joint pain
While current supplies of these novel medications are limited due to production bottlenecks (Lipanovic, 2024), one might expect a decrease in patient out-of-pocket costs due to expansion of production capacity (Novo Nordisk, 2024), increased market competition (Liu et al., 2021, Collins et al., 2024), expanded insurance coverage (Liu and Rome, 2024, Cubanski and Neuman, 2024), and, eventually, expiration of patent protections (Alhiary et al., 2023)
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10.1016/j.nupar.2021.10.001 77
Neurons from the VTA innervate the ventral striatum (nucleus accumbens), olfactory bulb, amygdala, hippocampus, orbital and medial prefrontal cortex, and cingulate cortex
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