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Second, the oral bioavailability of Dihexa is limited, and the compound's blood-brain barrier penetration remains uncertain at therapeutic doses in humans

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The relevance of the SEMA-K2 interface is supported by previous mutagenesis data showing that mutation of H241, Arg242, Lys244, and Arg249 in HGF significantly reduces its biological activity 19

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Medication leaking back out Sometimes after removing the needle, a small amount of clear fluid appears at the injection site