half life 1.5-3 hours excreted by the kidney (no metabolism) Side Effects: Rare : dose-related incidence of lactic acidosis GI side effects (diarrhea, nausea, vomiting, abdominal bloating, gas, reduced appetite) (~20% of patients develop dose-related GI side effects) Vitamin B12 deficiency
The starting dose for Ozempic is 0.25 mg, and the highest dose is 2 mg weekly
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Another promising advancement is CagriSema , a novel combination therapy that pairs cagrilintide (an amylin analog) with semaglutide (a GLP-1 receptor agonist)
In addition to these health concerns, a meta-analysis of 21 randomized trials has linked taking Ozempic to a significantly increased risk of blood clots
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