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[6] The investigators concluded that the lipolytic actions were not explained by direct beta-3-receptor activation, although increased receptor expression could contribute to enhanced lipolytic sensitivity after longer exposure
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in Nature Medicine found that NNMT inhibition in white adipose tissue increased energy expenditure and reduced fat mass in animal models without altering food intake or physical activity (Kraus et al., Nature Medicine )
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Their adipose tissues were collected and weighed for further analysis [2]
Adjusting the dose for each patients needs is vital for safe and effective treatment
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