Lets translate this into clinical reality Absolute risk reduction 3.7% over 3 years NNT 27 So yes this is clinically meaningful But heres the uncomfortable truth: This benefit is conditional
If you're nausea-sensitive, starting with GLP-1s or lower tirzepatide doses makes sense
At the end of the day, getting insurance to cover Ozempic for PCOS will be an uphill battle
Indeed, this week Lilly aims to begin a study that will test Mounjaro against Wegovy head-to-head in 700 participants at 61 sites in the United States and Canada, according to clinicaltrials.gov
Higashi Y, Aratake T, Shimizu T, Shimizu S, Saito M
Studies haven't shown any significant changes in hormone levels when taking both medications together