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It has been shown that patients with major depressive disorder have systemic and localized disorders of glucose metabolism throughout the course of the disease, disrupting various processes such as glucose uptake, glycoprotein transport, glycolysis, the tricarboxylic acid cycle and oxidative phosphorylation

Participants achieved 13.4% weight loss with 15mg tirzepatide versus 2.5% with placebo over 72 weeks

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This retrospective study included patients to illustrate the integration of TEAM therapies in Western academic settings

About 4% of patients discontinue tirzepatide due to intolerable side effects