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Endogenous fatty acids are essential signaling factors of pancreatic beta-cells and insulin secretion
Therefore, processes such as hypoxia and hyperoxia can disrupt oxidative balance and ultimately induce oxidative stress [12, 13], with ROS being one of the main participants [14]
Linda Marie Johnson, Administrator of the Estate of Kathleen I
Although current evidence supports broad applicability across BMI, diabetes status, and fibrosis stages F2-F3, subgroup analyses suggest attenuated responses in non-obese patients and in certain ethnic groups (Hispanic patients in ESSENCE), emphasizing the need for precision medicine approaches incorporating anthropometric, genetic (e.g., PNPLA3, HSD17B13), and metabolic profiling
doi: 10.1038/s41579-023-00998-9 298
Conclusions For patients who have had insufficient weight loss or weight recurrence following sleeve gastrectomy, conversion to RYGB offers greater, long-term weight loss compared to GLP1-RAs
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