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Symptoms of magnesium deficiency include irritability, difficulty with concentration, insomnia, depression, and anxiety

L-Carnitine may interact with certain medications

Given that both of these studies were in patients with OA of the knee (a load-bearing joint), it is likely that a significant proportion of the efficacy observed was due to the significant loss of body weight, reducing pathological joint loading

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However, higher concentrations also mean that small measurement errors translate to larger dose discrepancies

If discontinuation is necessary, tapering is recommended