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Combination formulations that include amylin analogs with other incretins like GLP-1, such as cagrisema, are currently being assessed for the treatment of obesity and metabolic disorders

On one hand, the cardiovascular protection afforded by SGLT2is seems to result from their beneficial hemodynamic effects, including improvement in ventricular preload (secondary to natriuresis and osmotic diuresis) and afterload (through blood pressure reduction), but also from improvement of cardiac metabolism (through the switch from utilization of glucose to ketones), inhibition of the myocardial Na + /H + exchanger, reduction of cardiac fibrosis and necrosis, reduction of proinflammatory adipokines derived from epicardial and perivascular fat, and stimulation of erythropoiesis (which can facilitate the release of oxygen to ischemic tissues) [1, 4, 14,15,16]

2) 3) 4) 5) 6) About the Author Originally authored by Thomas Jadallah

Its often used by those who want to improve their metabolic function, manage mild fatigue, or simply enhance their daily vitality

In the last 10 to 15 years, discoveries on certain gut peptides that influence insulin secretion related to meal ingestion, namely incretins, have opened up a new paradigm in the treatment of diabetes [4]