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For comparisons involving more than two groups, one-way analysis of variance (ANOVA) was applied to normally distributed data, followed by Bonferronis post-hoc correction to control for multiple comparisons

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After 6 and 12 months, growth rates, IGF-I, and GH-binding protein (GH-BP) levels increased similarly in all groups, indicating that GH timing does not affect treatment efficacy ( Exploring whether metabolic effect of growth hormone is equally beneficial with morning versus evening growth hormone (GH) injections in GH-deficient patients is crucial for tailoring optimal treatment plans for metabolic stability and overall health

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