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142C , 141148 (2006)
ERR target-gene expression (for example, Ppargc1a, Tfam, OXPHOS subunits), oxygen-consumption rate in cells, and, in vivo, indirect calorimetry parameters (energy expenditure, RER), plus mitochondrial DNA and cytochrome-c content in muscle
Moreover, null or inconsistent findings in some mechanistic trials, including absent changes in certain satiety hormones or mixed reward-response patterns, underscore the complexity of these pathways
In simple terms, L-Carnitine acts as a bridge between stored fat and energy utilisation
The weight loss these medications provide targets one of the root causes of the problem
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