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[6] Proposed mechanisms for cardiovascular benefits of incretin-based therapies include: Vascular effects : Improved endothelial function and reduced arterial stiffness Anti-inflammatory actions : Decreased systemic inflammation and oxidative stress Metabolic improvements : Enhanced insulin sensitivity and reduced hepatic glucose production Hemodynamic changes : Blood pressure reduction, though with modest increases in heart rate Renal protection : Reduced albuminuria and preservation of kidney function The cardiovascular benefits appear partially independent of weight loss itself, suggesting potential cardioprotective properties of incretin pathway activation
Now, new research suggests there may be another benefit: The combination of a GLP-1 drug with menopausal hormone treatment (MHT) may aid in weight loss more than a GLP-1 taken alone, and it may provide some cardiovascular benefits, too
Diabetes Obes Metab (2016) 18:4919
[49], with permission from Elsevier
Generally well tolerated
When people move away from unhealthy habits, they often build better relationships with food
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