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This difference supports a concept of testable synergy rather than simple redundancy

While generally safe, daily creatine has been linked to gastrointestinal (GI) problems and other side effects, including: Diarrhea or loose stools Nausea Vomiting Dizziness Excessive sweating, or hyperhidrosis Weight gain due to water retention Creatine may also worsen kidney problems among those who already have kidney disease

Therefore, mGSH arises from the cytosol GSH by the activity of specific carriers ( Figure 1

6 Exogenous iron sources, like ferric ammonium citrate (FAC), promotes ferroptosis, while iron chelators like deferoxamine (DFO) inhibit iron overload

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