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These compounds represent two distinct philosophies in multi-receptor agonist design
The post says tirzepatide is metabolized primarily via peptide hydrolysis rather than hepatic metabolism, so liver function plays a minimal role in clearance
Nielsen MS et al
It is not a peptide and does not have an amino acid sequence
If you use insulin or sulfonylureas, clinicians often plan closer glucose checks because changes in caloric intake and weight can lower insulin requirements
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