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The clinical study was carried out following guidelines for human studies with the approval of the Ondo State Health Research Ethics Committee (OSHREC), Ondo State (OSHREC 22/3/2021/316)

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Allergy and the gastrointestinal system. Clinical and Experimental Immunology

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Skin density, thickness, laxity, and fine-line appearance were assessed by clinician evaluation and instrumental measurement at baseline and after 12 weeks of twice-daily application

For the tirzepatideGIPRG s and non-acylated tirzepatideGIPRmini-G s complexes, GIPR and DNG s or mini-G s heterotrimer were co-expressed in High Five cells