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Serena Williams and Charles Barkley have both shared their first-hand weight loss experiences on Ro

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Whether retatrutide-driven weight loss replicates this in a randomized setting is unknown, but the magnitude of fat loss achieved in Phase 2 makes a favorable signal biologically plausible

"Way back, when there really weren't too many other agents for obesity treatment," she'd prescribe more of it, she told Insider, but that was largely because "there wasn't anything else." But metformin's effects on weight loss are "kind of mild," compared to newer drugs like semaglutide, Apovian said, and persistent side effects like stomach cramps and diarrhea are a common concern among patients taking metformin