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The topical application is particularly relevant for localized infections, such as skin wounds or mucosal infections, where direct delivery to the affected area can enhance efficacy and minimize systemic side effects

W., Crafts-Brandner, S

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382 SIRT3 and SIRT5 stabilize and activate the enzymatic activity of SHMT2 by its deacetylase and desuccinylase activity, respectively, thereby promoting the serine catabolism to drive carcinogenesis