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174,175 Several oncogenic mechanisms, such as the transcription factor HIF-1, PI3K/Akt/mTOR pathway and c-Myc, upregulate genes encoding glucose transporters and glycolytic proteins, including GLUT1, GLUT3, and lactate dehydrogenase (LDH)
Conversely, glutathione treatment reduces in a dosedependent manner oxidative stress as indicated by the reduction in H 2 O 2 levels (23.66.1 mol/L versus 39.87.3 mol/L for 5 mM of glutathione
Another effect of decreased GI motility is reflux, or GERD
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What the data shows: REDEFINE-1 (obesity without diabetes): 22.7% average weight loss vs 2.3% placebo | 91.9% achieved 5% weight loss REDEFINE-2 (type 2 diabetes + obesity): 14-16% weight loss sustained over 68 weeks Consistent GLP-1 class safety profile with potential for fewer GI side effects due to amylin co-agonism What this means for practice: This isn't just another weight-loss drugit's addressing the mechanistic gap in dual-pathway therapy
