Hormones (Athens) (2020) 19:2530
Under unfolded protein stress conditions, GRP78 binds to unfolded or misfolded proteins and subsequently activates downstream ER stress sensors, including IRE1, PERK, and ATF6, to trigger a response to unfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)
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Gastrointestinal side effects are the most common adverse reactions, particularly during dose escalation
Not only does ketamine exert rapid-acting antidepressant effects in animals and humans, but its IV administration is associated with normalization of spine, synapse, dendrite, and prefrontal cortical communication deficits within a few hours