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After 12 h incubation, cells were treated with PBS, Ru(II)-OH, NP2, or NP4 for 24 h (Ru 10 M), washed with PBS and incubated with Annexin/PI reagent in the dark for 15 min at 25 C

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This intervention results in a reduced abundance of granulocytic myeloid-derived suppressor cells (G-MDSCs) and M2-like tumor-associated macrophages (TAMs), thereby triggering an anti-tumor response from CD8+ T cells ( At the same time, Fu et al

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BPC-157 is typically administered as a small subcutaneous injection, though it may also be taken orally depending on the treatment goal, oral administration is particularly relevant for gut-related concerns

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