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E2 and PROG are key physiological components for implantation and maintenance of pregnancy [40, 41], the decline of which may result in insufficient nutritional and metabolic support for the fetus, and further impair the development and survival of fetal germ cells, ultimately leading to a reduction in germ cell number

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Statements Author contributions XD: Conceptualization, Data curation, Formal Analysis, Methodology, Project administration, Writing original draft