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In the Prenatal THC/stress group, upregulated genes were enriched for startle response, dendritic spine development, and glutamate-receptor binding, whereas downregulated genes involved cellular respiration, plasma membrane receptor complexes, and integrin binding, indicating altered synaptic excitability and cellular energetics

Nat Rev Mol Cell Biol 8(10):761773

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First, several of these compounds are promoted for their effects on blood vessel growth, and NPR reported FDA raised concerns about the potential to encourage cancer growth. If you have a cancer history, that is not a small footnote

Lipidome profile predictive of disease evolution and activity in rheumatoid arthritis

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