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Key limitations include: No completed randomized controlled trials in humans Most data derived from animal models, limiting direct translatability Publication bias may favor positive results Long-term safety data in humans is not available Optimal dosing for human applications has not been established Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers , published in Journal of Alternative and Complementary Medicine (Allen J and Bradley RD, 2011
A better strategy is using melatonin during the initial weeks while Epitalon takes effect, then tapering off the supplement as natural production increases
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