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The plate was incubated for further 30 min at 37 C without CO 2 for equilibration and then inserted into a Seahorse XFe96 Analyzer (Agilent Technologies) loaded with a hydrated cartridge, for measurement

Tripeptides such as GHK-Cu have an established safety record in topical and cosmetic applications, showing low cytotoxicity and reduced skin irritation compared with other copper compounds, and acceptable tolerability in clinical cosmetic studies [23, 74, 93]

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Researchers have also explored DSIPs possible role in stress regulation, hormone signaling, and pain modulation, but the overall evidence remains preliminary and insufficient for definitive clinical recommendations

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CHAC1 inactivation is effective to preserve muscle glutathione but is insufficient to protect against muscle wasting in cachexia