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Discussion In this pilot post hoc epigenetic analysis of the SLIM LIVER trial, we evaluated whether changes in epigenetic aging biomarkers, specifically DunedinPACE, PCGrimAge, and PCDNAmTL, were associated with anthropometric, metabolic, and physical function changes over 24 weeks of semaglutide treatment in PWH and MASLD

Type II PRMTs (PRMT5 and PRMT9) catalyze the formation of symmetrical dimethylarginine