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Serious deficiency can impair heart and neurological function, leading to a wide range of symptoms, including tinnitus, severe joint pain, memory problems, depression, anxiety and poor muscle function

The National Institutes of Health Office of Dietary Supplements has not set a Tolerable Upper Intake Level for B12 precisely because no reliable evidence of harm from high intakes has been established in healthy people

Administration And Dosage Administration is by deep intramuscular injection into the neck area

On top of that, proper function of the folate cycle is also required for synthesizing and regenerating a cofactor needed for the production of neurotransmitters (serotonin, melatonin, dopamine, noradrenaline, adrenaline) and nitric oxide

(20) Intestinal problems: Because B12 is absorbed in the intestines, any disease that impairs intestinal function can interfere with B12 absorption

THF plays an important role in DNA synthesis, so reduced availability of THF results in ineffective production of cells with rapid turnover, in particular red blood cells, and also intestinal wall cells which are responsible for absorption