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Mechanisms of Ageing and Development, 125(2), 113-115
ani M, Stanimirov B, Pavlovi N, Goloorbin-Kon S, Al-Salami H, Stankov K, et al
Because MOTS-c is naturally produced in response to exercise, and because it activates the same AMPK and mitochondrial biogenesis pathways that exercise training upregulates, combining exogenous MOTS-c with a structured exercise program creates a reinforcing signal that operates through the same biological channels
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Owing to its high concentration in the cell (~10 3 M) 1 , the GSH/GSSG pair acts as the main intracellular redox buffer, plays a key role in the detoxification of reactive oxygen species (ROS), and participates in redox signalling 2
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