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Common reasons for stopping include achievement of weight goals, intolerable side effects, cost or access issues, pregnancy planning, or patient preference
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Most treatment discontinuations were due to gastrointestinal AE and occurred during the rapid escalation phase this may be mitigated with more gradual dose escalation at phase 3 trials
Growth hormone and IGF-1 may promote tumorigenesis by enhancing cell cycle progression and inhibiting apoptosis. Pollak, M., Nature Reviews Cancer IGF-1 LR3 Side Effects 1
Immune Modulation Studies: Investigated for its influence on inflammatory activity and immune response balance
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