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The significant changes in antioxidant enzyme activity after GSH depletion suggest that thiol status can influence the regulation of other antioxidant enzymes

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Anti-Inflammatory Effects: Inflammation is known to influence the secretion and regulation of growth hormones

The paper remains the most-cited single source for GHK-Cus pleiotropic gene-expression effects and is a primary reference for the compounds research applications in dermal aging, wound healing, and oxidative stress models

Additionally, the mortality rate in the peptide subjects appeared to significantly decrease, with a 2-fold decrease in the Thymalin subjects, a 1.8-fold decrease in the Epithalon subjects, and 2.5-fold decrease in the subjects presented with both peptides

Rather than acting through a single mechanism, this peptide appears to coordinate multiple healing processes simultaneously, which may explain its consistent effectiveness across different wound types and tissue locations