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6.2 Irisin and the endocrinology of exercise Irisin, a peptide cleaved from the transmembrane protein FNDC5 and released from skeletal muscle during exercise, represents a parallel and more controversial example of muscle-derived endocrine signaling

Wiley Encyclopedia of Chemical Biology

doi: 10.1016/j.neuint.2020.104707 12 BaeCSSongJ

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Furthermore, the buildup of ototoxic drugs within hair cell mitochondria can result in drug-induced hearing loss (Tan and Song 2023)