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Simultaneously, 5-LOX is recruited to the nuclear envelope, where it binds to the 5-LOX-activating protein (FLAP) and acts on AA to generate leukotriene A4 (LTA4)

Electrocardiogram monitoring revealed no cardiac conduction abnormalities or other cardiovascular concerns

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Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts