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Some of the mentioned molecular mechanisms are visually summarized in Figure 1, which illustrates ASTs modulation of key pathways such as Nrf2/ARE, PI3K/Akt, and NF-B in promoting neuroprotection
Interestingly, in toxin-based animal models of PD the depletion of dopaminergic neurons in the SNpc is aggravated in animals that were concomitantly submitted to a high fat diet regimen (Ma et al., 2015), suggesting that this diet may increase the susceptibility of animal to PD-inducing drugs
If sterile water without preservative is used, use within 24-48 hours
Sample means for each decile are shown as green circles (for observed data) or red squares (for sample predictions), with error bars representing 95% confidence intervals
The prevailing sentiment is that the two are complementary, and the Wolverine Stack pairing is discussed more often than an either/or decision
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