when used incorrectly, they might lead to irritation
Also, during STEP 5, a study to assess efficacy of semaglutide with a follow-up of 2 years, there is a post-hoc analysis that demonstrates a better performance in the self-reported Control of Eating Questionnaire(CoEQ) to measure changes in appetite versus placebo, with lower cravings for dairy and starchy foods and less desire for salty and spicy food at short-term (20 weeks) but also as a maintenance therapy at weeks 52 and 104 (178)
4,5 GI side effects like nausea, vomiting, or diarrhea are common, but symptoms may decrease with continued use
A major consideration in the application of GLP-1 RAs to PD is their metabolic impact
A review of the pharmacotherapy of obesity: GLP-1 receptor agonists
It also disrupts T cell proliferation, activation, and effector cytokine expression by specifically depleting the extracellular space of glutamine through the inhibition of cMyc and IRF4 expression (Wstner et al., 2015)